Can you cut Anders down in New Vegas?

Yes, you can cut Anders down in Fallout: New Vegas as part of the "Aba Daba Honeymoon" quest; you find him crucified in Vault 3, and after talking to him (or using a high Speech check to bypass confrontation), you can free him by cutting him down or convincing him to leave, which allows you to proceed with the quest for Diane and Jack. However, he is bugged to die if any Fiend damages him, so freeing him requires either a Speech check to convince him to leave, or freeing him and quickly dealing with the Fiends, though you can also just kill him for mercy or leave him if you don't want to deal with the consequences,.
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Can you let Anders down in New Vegas?

Once freed from the cross, his leg will be crippled and will limp both once released and when seen walking around back at the drug lab. He can only be let down from the cross once the quest Aba Daba Honeymoon is active.
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Can you cut down Anders?

One has three options to deal with Anders: Talk to him to confirm he's Anders and then cut him down (this will not cause infamy with Caesar's Legion.) Talk to him to confirm he's Anders and leave him (this will delay progress in the quest). Kill him, with or without talking to him first.
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Can ED-E be killed?

One can lose ED-E without noticing its death in battles or if it strays too far from the player by its own way being in [DANGER] mode because of the hostiles around it. A related bug exists where if ED-E is destroyed, its perk still remains in the player's Pip-Boy and still fully working.
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Is it better to take ED-E to followers or brotherhood?

In Fallout: New Vegas, the choice for ED-E's upgrade depends on whether you want better defense or offense: the Brotherhood of Steel gives ED-E an armor upgrade (more Damage Threshold/DT), making him tougher; the Followers of the Apocalypse upgrade his weapon (more damage, critical chance, special attack), improving his damage output, but some find the sound annoying. Choose BoS for defense/tanking (especially on Hardcore mode) or Followers for more direct damage, with the choice also affecting faction standing and roleplaying. 
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Aba Daba Honeymoon - Shooting Anders (Fallout New Vegas)

Can you save danse without betraying the Brotherhood?

Yes, you can save Paladin Danse without permanently betraying the Brotherhood of Steel by succeeding in the high-Charisma speech checks during the "Blind Betrayal" quest, convincing both Danse to live and Elder Maxson to spare him, leading to Danse's banishment but keeping the Brotherhood intact (especially if you side with the Minutemen for the ending). While you can avoid killing him and keep him as a companion, he'll be exiled, and siding with other factions (like the Railroad or Institute) eventually forces a conflict with the BoS, but you can navigate this to keep Danse and the Brotherhood alive by completing the game as a Minuteman.
 
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Do you lose ED-E after Lonesome Road?

Mild spoiler, but ED-E leaves you at the end of Lonesome Road (and if you've been listening to the recordings, you probably know why and where it's going). You can delay going to Ulysses' Temple until then. Finish up the whole zone - get all the upgrades, find the Elite Riot armor, do whatever you need.
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Who is the best faction to side with in Fallout: New Vegas?

The "best" faction in Fallout: New Vegas depends on your playstyle and morals, but common choices are the NCR for restoring democracy and order (despite corruption), Mr. House for technological progress under benevolent dictatorship, Caesar's Legion for brutal conquest and strict societal order, and Yes Man/Independent for ultimate player control, while the Followers of the Apocalypse are seen as the most purely "good" but less powerful group. 
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Should I take ED-E to the scrapyard?

To trigger the first message, one must bring ED-E to one of the following events: Old Lady Gibson at the Gibson scrap yard, as Johnson Nash suggested. (If her conversation options have already been gone through before starting this quest, talking to her will no longer trigger this message.)
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Can you get Benny's gun if you crucify him?

The weapon can only be found in 100% condition on Benny if one he is killed directly either during Ring-a-Ding-Ding! or Render Unto Caesar. It may also be pickpocketed from him. It becomes unobtainable if Benny was chosen to be crucified during Render Unto Caesar.
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Can you sleep with Red Lucy in New Vegas?

Yes, you can sleep with Red Lucy in Fallout: New Vegas after completing her "Bleed Me Dry" quest by bringing her giant mantis eggs, which unlocks an intimate "fade-to-black" encounter for a "Well Rested" bonus, regardless of your character's gender. This interaction is part of her unique "romance" arc where she rewards your successful hunting efforts with companionship, noting that even strong creatures need rest. 
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Who actually sold Boone's wife?

In the video game Fallout: New Vegas, Jeannie May Crawford, the motel owner in Novac, sold Craig Boone's pregnant wife, Carla, into slavery to Caesar's Legion for 1500 bottle caps, a fact revealed in a "Bill of Sale" found in a safe, leading to a quest where the player helps Boone get revenge. 
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Can you sleep with Sarah FNV?

After the player character has brought her 30 vault suits, on each visit thereafter, she will mention that she's missed the player. The player will then be given the option to sleep with her while "catching up", giving the Well Rested bonus (which is normally not earned by sleeping in Vault 21's guest room).
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What is the hardest enemy in Fallout New Vegas?

The strongest enemy in Fallout: New Vegas is often considered the Legendary Bloatfly from the Old World Blues DLC due to its high health (2,000), powerful plasma attacks, and explosive death, though formidable foes like Alpha Deathclaws, especially the Mother Deathclaw, and deadly Cazadores also rank high, with some players finding even tough NCR Veterans or unique DLC creatures challenging depending on their build and location.
 
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Is it possible to spare a Dean Domino?

Curtain Call at the Tampico: The player character has to confront Dean in the Sierra Madre Casino & Resort in the Tampico and can choose to either let him go free or kill him.
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Is it better to take Ede to followers or Brotherhood?

In Fallout: New Vegas, the choice for ED-E's upgrade depends on whether you want better defense or offense: the Brotherhood of Steel gives ED-E an armor upgrade (more Damage Threshold/DT), making him tougher; the Followers of the Apocalypse upgrade his weapon (more damage, critical chance, special attack), improving his damage output, but some find the sound annoying. Choose BoS for defense/tanking (especially on Hardcore mode) or Followers for more direct damage, with the choice also affecting faction standing and roleplaying. 
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Are Powder Gangers good or bad?

Though Powder Gangers almost all have Evil Karma, the larger Powder Ganger faction is not marked as Evil. This means that stealing items owned by the Powder Gangers faction will incur negative Karma.
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What is the most moral faction in Fallout: New Vegas?

I'd say The Followers of The Apocalypse are the most ethical faction in the game. They're basically a humanitarian organization that offers cheap medical supplies, rehabilitates addicts, and tries to research technology for the betterment of mankind. The Kings are also pretty rad guys.
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Will Veronica hate me if I destroy the Brotherhood?

Telling her about destroying the Brotherhood will cause her to express shock and lead her to say, "Well in that case: This is for them," and attack. Becoming Vilified with the Brotherhood of Steel causes Veronica to quit as a companion.
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Can you stop President Kimball from being assassinated?

Prevent President Kimball's assassination. Locate and disarm the bomb planted on the president's Vertibird (requires 50 Explosives/Repair) or pickpocket the detonator from the assassin disguised as an NCR engineer. Locate and defeat the assassin disguised as an NCR Ranger on top of the sniper tower behind the stage.
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Can you go back to the divide after you finish Lonesome Road?

Can you return to the divide after completing Lonesome Road | Fandom. Yes, the only DLC area that you cannot return to after completing the DLC is the Sierra Madre.
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What happens if you tell Yes Man to ignore a faction?

Telling Yes Man to ignore a faction in Fallout: New Vegas means you skip their side quests, don't gain them as allies for the final battle at Hoover Dam, and they remain neutral (or in their default state), resulting in different post-game slides and potentially missing out on content or unique rewards, essentially letting them live but not actively involve them in your independent New Vegas takeover. 
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Is there a max level in FNV?

Fallout: New Vegas has a fixed character level limit of 30 (50 with the four add-ons; each raises the level cap by 5 levels).
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