Can you do mass fusion in Fallout 4?

Yes, you can do the "Mass Fusion" quest in Fallout 4, and it's a major main story mission where you choose sides, typically siding with the Institute or the Brotherhood of Steel (BoS), but you can also work towards a Minutemen ending if you play your cards right. This quest involves infiltrating the Mass Fusion building for a beryllium agitator, but your actions there will make you enemies with one of the major factions, locking you out of their subsequent quests unless you're careful.
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What happens if you do Mass Fusion in Fallout 4?

When ready to continue, take the central elevator up to the Relay room. Upon entering the relay, one will get a warning that relaying to the Mass Fusion building will make them a permanent enemy to the Brotherhood of Steel.
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How to start Mass Fusion in Fallout 4?

Go to the Institute and talk to the yellow department head to receive the Mass Fusion quest. DO NOT go with her to the teleporter.
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Can I do Mass Fusion without angering Brotherhood?

Yes you can. Yes, you can, and they wont mind so long as you don't Attack the Railroad, or initiate Mass Fusion on the BoS side. What is the name of the quest that has you attack the railroad, and is there anyway to convince them not to? Or come out of that quest with both sides liking you?
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Where is the Mass Fusion building in Fallout 4?

The Mass Fusion Building in Fallout 4 is a tall, ruined skyscraper in downtown Boston, located north of Goodneighbor and west of the Old Corner Bookstore, acting as a key location for late-game quests, especially for the Institute and Brotherhood of Steel, requiring specific access to reach its upper levels and reactor core.
 
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Fallout 4 - Mass Fusion for the Institute without making the Brotherhood hostile (the easy way!)

How to get unlimited fusion cores in Fallout 4?

To get "unlimited" Fusion Cores in Fallout 4, you can exploit the pickpocketing glitch with Power Armor NPCs (like Brotherhood members) by saving/reloading, farm them from Sentry Bots, or use console commands on PC; alternatively, you can buy them from vendors (like Cleo in Goodneighbor) using caps earned from selling Purified Water, or install a mod that allows recharging or crafting them. 
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What happens if I fly to Mass Fusion?

There is a Vertibird docked on the Prydwen's flight deck that will fly to the roof of the Mass Fusion building when the player character is ready to go. Upon boarding, a message will appear warning the player that boarding the Vertibird will officially make the player character an enemy of the Institute.
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Who is the real villain in Fallout 4?

The main villain in Fallout 4 is Shaun, also known as Father, the leader of the high-tech Institute and the adult son of the player character, the Sole Survivor, who seeks to replace humanity with synths and uses his parent as a pawn in his plan to take over the Commonwealth. Other antagonists include Conrad Kellogg, the mercenary who kidnaps Shaun, and the entire Institute, as well as other factions like the Minutemen, Brotherhood of Steel, and Railroad having morally grey or villainous elements depending on player choice. 
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Can you save danse without betraying the Brotherhood?

The quest can be avoided, retaining Danse's good standing with the Brotherhood, by one of these means: Not giving the network scanner tape (nor a copy) to Proctor Ingram. Not completing (or failing) Liberty Reprimed. However, avoiding this quest prevents ever reaching maximum affinity with Danse.
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Is it better to return or deliver the Deathclaw egg in Fallout 4?

Putting the helmet on after completing the quest by returning the egg will immediately turn the deathclaw hostile. Berry Mentats will also trigger a hostile status. If one delivers the egg for the reduced reward having stolen it back from the nest a pristine deathclaw egg may remain in the player's inventory.
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What choices affect Fallout 4's ending?

Unlike previous games, the Fallout 4 ending cutscene does not change based on how the Sole Survivor has finished most quests or interacted with other people. Only the choice of completing Nuclear Family or The Nuclear Option has any effect on the ending.
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Does Piper get mad if you join the Brotherhood of Steel?

She also has an open dislike for the Brotherhood of Steel due to their self-serving nature, technology hoarding, anti-synth policies, and in her eyes, lousy fashion sense. Thus she will react negatively to any pro-Brotherhood choices.
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What's the best faction to join in Fallout 4?

There's no single "best" faction in Fallout 4; it depends on your playstyle and morals, but generally, the Railroad (for stealth/espionage rewards like Ballistic Weave) and Brotherhood of Steel (BoS) (for Power Armor/heavy weapons) offer great perks, while the Minutemen (for a true "good guy" feel and settlement focus) are morally sound but less rewarding, and the Institute is often seen as the villainous, technologically advanced, but morally corrupt choice.
 
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Should I give 3 fusion cores to Vault 81?

McNamara will advise the player character that if they want to enter the Vault, they need to bring three fusion cores as a means of payment. Alternatively, the Sole Survivor may pass a Hard Charisma check. If the choice is made to part with the cores, they will be compensated with 100 bottlecaps by the overseer.
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Does completing Mass Fusion make Brotherhood hostile?

Yes, the Mass Fusion quest is a major turning point in Fallout 4; completing it for the Institute will make the Brotherhood of Steel permanently hostile, forcing you to fight them, while warning the Brotherhood makes the Institute your enemy. This choice breaks your alliance with one faction, locking you into either the Brotherhood/Minutemen path or the Institute/Railroad path for the endgame, depending on your decision. 
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Is it better to join the Institute in Fallout 4?

Whether you should help the Institute in Fallout 4 depends on your character's goals, as they offer advanced tech for rebuilding but have morally questionable methods like synth replacement; it's a choice between sterile progress (Institute) versus messy freedom (Railroad/Minutemen/Brotherhood), with the Institute being best for a self-serving, tech-focused player who wants to lead a future, but worst if you value surface-dweller lives and freedom over scientific advancement. 
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How to tell if a settler is a synth in Fallout 4?

To tell if a settler is a synth in Fallout 4, the most reliable in-game methods involve checking for high Energy Resistance in VATS (after stripping clothes) or using console commands on PC (like sv to find blsSynth = True). Without mods, it's difficult, but some players use trial-and-error by saving, killing them to check for a Synth Component in their inventory, or looking for unusual behavior or high Energy Resistance (ER) in VATS, as synths have innate ER. 
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Is CX404 dogmeat from Fallout 4?

Yes, CX404 from the Fallout TV show is the series' version of the iconic companion Dogmeat, a nod to the beloved German Shepherd in Fallout 4 and other games, but CX404 is a distinct Belgian Malinois with her own Enclave origin story, connecting the show's narrative to the games.
 
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Can you befriend a deathclaw in Fallout 4?

Yes, you can tame Deathclaws in Fallout 4, primarily through the Wasteland Workshop DLC to capture them in cages for your settlements or, uniquely, through the Devil's Due quest to get a permanent, named companion by returning its egg. The DLC method involves building cages and using Beta Wave Emitters to pacify them for settlement defense or arena battles, while the quest offers a free-roaming friend. 
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Can you steal fusion cores in Fallout 4?

It is possible to pickpocket fusion cores from characters equipped with power armor, such as Clint and Tessa at the Quincy ruins, Slag in Saugus Ironworks, Brotherhood of Steel members, and Atom Cats. Successfully pickpocketing it will force its user to exit the power armor.
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How many star cores do you need in Fallout 4?

In Fallout 4: Nuka-World, you need 20 Star Cores to fully secure the Galactic Zone and disable all security robots for your takeover, which is needed for the "Star Control" quest. However, to unlock the display case holding the Quantum X-01 Power Armor, you must find and install all 35 Star Cores available in the DLC.
 
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Can you run out of fusion cores in Fallout 4?

Yes, you can run out of Fusion Cores if you're extremely wasteful (like using the Jetpack constantly or never scavenging), but it's very difficult in Fallout 4 because they are abundant from vendors, loot (especially in ammo boxes), and enemies (Sentry Bots, Power Armor users), and you can even sell nearly depleted cores for full price, making them a sustainable resource with smart play. 
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