Can you get the R Key twice in one run?

Yes, you can get the R Key twice (or even more) in a single run in The Binding of Isaac, though it's very rare, often requiring breaking the game with items like The Schoolbag, ? Cards, or Wild Cards, or exploiting specific item pools in the Void. It usually involves using the R Key, restarting the run, and then finding another R Key in the reset run, sometimes with the help of synergies like Glitched Crown to exhaust pools and force new spawns.
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Is R Key better than a victory lap?

I think one of the reason R Key is considered better is because it can save a run. You're not beating the lamb and getting access to a victory lap if you have shit items (unless you're the ultimate skill solution) but an R Key can save a bad run at the press of a button when things go south.
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How long does it take to 100% TBOi rebirth?

When focusing on the main objectives, The Binding of Isaac: Rebirth is about 5½ Hours in length. If you're a gamer that strives to see all aspects of the game, you are likely to spend around 376 Hours to obtain 100% completion.
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Does the R Key prevent unlocks?

True Co-Op players can be spawned in at the first room after using the R Key. If used in a run while achievements and character unlocks are enabled, they will still be enabled after use. Similarly, if these are disabled because the player is in a Victory Lap or seeded run, they will remain disabled after use.
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Does the R Key reset item pools?

Item pools are NOT reset.
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2 R KEYS IN ONE RUN - The Binding of Isaac: Repentance

What is 1001% Isaac?

It unlocks when you have around 276 secrets, that was the total o secrets of Afterbirth, every DLC has its own 100% complete achievement, it's not bugged, you have the number of secrets to unlock the achievement, everything is fine.
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Can you do hush after R Key?

Using R Key now resets the timer completely, allowing for another go at Boss Rush or Hush.
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Is unlocking the same as rooting?

Rooting is distinct from SIM unlocking and bootloader unlocking. The former allows for the removal of the SIM card lock on a phone, while the latter allows rewriting the phone's boot partition (for example, to install or replace the operating system).
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Can you take both polaroid and negative as Jacob and Esau?

Jacob and Esau, proper alignment of both characters can enable picking up both The Polaroid and The Negative. With frame-perfect timing and a bomb, it is possible to pick up both The Polaroid and the Negative.
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How to unlock the Dark Room?

To unlock the Dark Room in The Binding of Isaac, you generally need to defeat Satan five times to get The Negative, allowing you to enter via his chest in Sheol; alternatively, you can use Sacrifice Rooms repeatedly in Sheol (12+ uses for a chance), find trapdoors in Black Markets/I AM ERROR rooms, or use certain items like Dad's Key to access it for the final fight against The Lamb. 
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What game took 9 years to make?

Too Human: 1999-2008 (9 years)

Too Human had one of the longest and strangest roads to release in gaming history.
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What does 1001% mean in Isaac?

In reality this just means it just means you have completed enough of the game that it would count as 100%ing a previous expansion. The latest and most sought-after of these 100% achievements is "Dead God", which is considered to be the "true" 100% achievement for repentance.
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Is Isaac 2 confirmed?

“I can say with certainty that there will eventually be another Isaac game,” said the creator. He went on to say that it will be a fair few years of waiting for the follow-up, stating that he plans to finish Mewgenics and any possible DLC for that game first.
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Does the R key reset magic skin?

R Key changes the map of previous floors, while the current floor's layout remains the same. Using R Key will not prevent Magic Skin from showing up if it has been used before.
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Is victory lap rare?

Supported Game Modes

Victory Lap is an Uncommon Pickaxe in Fortnite that can be purchased in the Item Shop for 500 V-Bucks, with the Racer Royale Bundle for 1,600 V-Bucks, or with T-Pain's Locker Bundle for 2,600 V-Bucks. Victory Lap was first released in Season 4 and is part of the Racer Royale Set.
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Is Jacob or Esau better?

Jacob has less damage and shot speed, while Esau has negative luck, less health and less tears. Even though both have the same base range, Jacob's shot speed reduces his effective range. Apart of that, speed and range are the same as Isaac, so individually there's no much difference from playing Isaac.
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Why would God choose Jacob over Esau?

God chose Jacob over Esau before they were born, not based on merit, but according to His sovereign plan of grace, demonstrating that His calling isn't earned, but given freely, though Jacob's deep desire for the spiritual blessing and Esau's despising of his birthright revealed character differences. God's choice was for His purposes, making Jacob the ancestor of Israel, highlighting His choice of the seemingly less-deserving to fulfill His covenant promises, a theme repeated in scripture. 
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Why is rooting illegal?

Even though rooting Android isn't illegal, manufacturers try to fight it. Gaining root access will immediately void your phone warranty. If something happens to your software or hardware, you won't get it fixed by the phone provider. Your Android phone is more vulnerable to malware and hacking.
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Should I unlock the bootloader?

Some developers and enthusiasts unlock and root in order to experiment with applications or with custom builds of Android. NOTE: Unlocking the Bootloader is unnecessary for the majority of users, and is not recommended.
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Will unrooting delete everything?

A: Most unrooting methods try to preserve your data, but some (especially flashing stock firmware) will erase it.
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How many hours to 100% TBOi?

Completing The Binding of Isaac (especially with all DLC like Repentance) to 100% can take anywhere from 150 to over 600 hours, with many dedicated players averaging around 300-400 hours, depending heavily on skill, luck, and if you're aiming for "Dead God" (all achievements/completion) or just "Real Platinum God" (main completion). Some estimates for the most challenging achievements suggest potentially thousands of hours, but a focused completionist can finish well within a few hundred. 
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Can dad's key open hush?

No, Dad's Key cannot open the door to the Blue Womb (Hush's floor) from the outside if you've passed the 30-minute timer, but it can open other locked doors like Mega Satan's or secret rooms, and it can open the Hush door from the inside to exit the room after the fight. The key is that Dad's Key won't work for time-sensitive boss doors (Hush/Boss Rush) once their time limit is up, though it will open regular rooms on that floor. 
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