Does Genesis reset item pools Isaac?

No, Genesis in The Binding of Isaac does not reset item pools; instead, it takes items you've collected, places them back into their original pools, and offers you three new choices from those same pools, effectively letting you re-pick items but keeping the pool's composition intact, only removing certain unremovable items like Key Pieces or Polaroid/Negative.
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How do item pools work in Isaac?

In The Binding of Isaac, every object or room that has a chance of spawning an item (Boss Rooms, Golden Chests, etc.) has a specific item pool from which it draws, ensuring that the item obtained is appropriate.
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Does the R key reset item pools?

Item pools are NOT reset.
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What item restarts a run in Isaac?

R Key originates from the Antibirth mod. This item is a reference to how holding down the R key on PC will restart a run. This item is very similar to Clone from Enter the Gungeon. The only difference is that R Key is an activated item while Clone is a passive item that activates upon death.
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What is 1001% Isaac?

It unlocks when you have around 276 secrets, that was the total o secrets of Afterbirth, every DLC has its own 100% complete achievement, it's not bugged, you have the number of secrets to unlock the achievement, everything is fine.
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The Best Genesis Reset In The Binding Of Isaac Repentance

How many hours to 100% TBOi?

Completing The Binding of Isaac (especially with all DLC like Repentance) to 100% can take anywhere from 150 to over 600 hours, with many dedicated players averaging around 300-400 hours, depending heavily on skill, luck, and if you're aiming for "Dead God" (all achievements/completion) or just "Real Platinum God" (main completion). Some estimates for the most challenging achievements suggest potentially thousands of hours, but a focused completionist can finish well within a few hundred. 
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Why is R Key good in Isaac?

R Key can be used on The Chest or Dark Room to completely restart a run and get even more items.
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Does diplopia duplicate chests?

Diplopia copies the entire effect of any item, to a point where Edmund ruled that using Diplopia on a Guppy piece will count towards Soul of Guppy. The Chest's effect is that it becomes a soul when it's destroyed. Thus, if Diplopia carrying this effect is destroyed, it obeys this effect and becomes a soul.
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What happens after killing Isaac 5 times?

After defeating Isaac 5 times you'll unlock the Polaroid item, it will appear every time you defeat Mom.
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Can you do hush after R Key?

Using R Key now resets the timer completely, allowing for another go at Boss Rush or Hush.
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What does Alt+F2 do in Isaac?

Add ALT + F2 shortcut on Stats page to import Steam achievements.
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Is Isaac appropriate for kids?

The Binding of Isaac: Repentance is rated M for Mature 17+ by the ESRB with Blood and Gore, Crude Humor, Language, Use of Drugs, and Violence.
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What does the D1 room do in Isaac?

In The Binding of Isaac, the Dice Room with a single dot (1 pip) rerolls all your held items, transforming your active item into a passive one and changing your passive upgrades into different passive items, similar to the D4, but can be risky as it might leave you with nothing useful or even unable to attack. It essentially "dice-rolls" your current build, potentially swapping out your active item for a passive one and changing your passive abilities, so it's best used when your build is weak or you need a major change.
 
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Can diplopia be permanent?

No, double vision (diplopia) isn't always permanent; it can be temporary and resolve with treatment, but it can become long-lasting or permanent if the underlying cause isn't fixed, especially if the brain adapts, potentially leading to amblyopia (lazy eye). Recovery depends heavily on the cause, ranging from quick fixes like eye patches or prism glasses to managing serious issues like nerve palsies, diabetes, or brain conditions with medication or surgery, so prompt medical evaluation is crucial. 
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What does a red patch do in TBOi?

The Red Patch is a trinket in The Binding of Isaac that gives you a chance (starting at 20% and increasing with Luck) to gain +1.8 damage for the current room every time you take damage, making you look like a Dople. It's a risky but potentially rewarding item, especially good for characters like Tainted Maggie, who benefit from taking damage, as the damage bonus stacks and lasts for the room you got hit in.
 
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Can dad's key open the hush door?

No, Dad's Key cannot open the door to the Blue Womb (Hush's floor) from the outside if you've passed the 30-minute timer, but it can open other locked doors like Mega Satan's or secret rooms, and it can open the Hush door from the inside to exit the room after the fight. The key is that Dad's Key won't work for time-sensitive boss doors (Hush/Boss Rush) once their time limit is up, though it will open regular rooms on that floor. 
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Why is Mom's knife so good?

Effects. Isaac's tears are replaced by a knife that pierces enemies and can travel through obstacles. Holding down the fire button increases its range and power. The knife deals damage 20 times per second upon contact with enemies while Isaac is holding it.
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What does 1001% mean in Isaac?

In reality this just means it just means you have completed enough of the game that it would count as 100%ing a previous expansion. The latest and most sought-after of these 100% achievements is "Dead God", which is considered to be the "true" 100% achievement for repentance.
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