What to do in Binding of Isaac after beating Mom?

After beating Mom, you've only just begun; you need to beat Mom's Heart/It Lives 11 times to unlock alternate paths to Sheol (Satan) and the Cathedral (Isaac), then collect the Negative (from Satan) and the Polaroid (from Isaac) to access the final floors, The Dark Room (The Lamb) and The Chest (Blue Baby), progressing to new endings and unlocking more content like Hush, Mega Satan, and ???.
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What happens after beating Mom Isaac?

After beating Mother, leave the game and enter again. A boss room door will spawn and will take you out of the Mother room. If there is a sacrificial room, take at least 12 hits and you'll get teleported to the Dark Room. Other than that, you just can use an R key.
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What do I do after I beat mom's heart?

After Mom's Heart come two separate paths, one for the Cathedral (light beam) and another for Sheol (trap door), with each having their own final boss fight. Defeating Mom's Heart 11 times will also unlock it's harder variant called It Lives!.
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What happens when you beat mom's heart 11 times?

After being killed 11 times, Mom's Heart is permanently replaced by It Lives. However, even after being replaced by It Lives, there are a few circumstances in which Mom's Heart can still be fought: It can still appear in the Nightmare Boss wave of Chapter 4 in Greed/Greedier Mode.
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Is Mom the final boss of Isaac?

Mom is not the final boss. There are several hidden bosses and 16ish endings. Beating Mom is but one step in a long series to truly beat the game.
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The Ultimate 5-Minute Progression Guide to The Binding of Isaac

What does beating Mother unlock?

Defeating Mom for the first time changes the current savefile's image and will allow unlocks to be obtained with mods enabled. XV - The Devil? during the Mom boss fight kills her instantly and unlocks The Halo.
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Is Isaac's Mother evil?

Moriah, better known as simply Mom, is the main antagonist of The Binding of Isaac franchise. She is the abusive, highly religious mother of Isaac.
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Why is Mom's knife so good?

Mom's Knife is so good in The Binding of Isaac because it offers immense, consistent damage, effectively bypassing boss armor and clearing rooms quickly, acting as a powerful melee weapon or a long-range, piercing projectile that scales with your damage stat, making it a game-winning item despite its learning curve and sometimes underwhelming synergies.
 
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What happens after you beat mom?

Every time you defeat Mom's Heart there's a chance to spawn an angel room, if you have defeated it 11 times a trapdoor or a beam of light will always appear after the battle, enter the beam of light and defeat the final boss Isaac.
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Who is first priority, mom or wife?

While honoring your mother, your wife generally comes first after marriage, forming a new, primary family unit, according to many relationship experts and traditional/biblical perspectives. Prioritizing your spouse builds a stronger marriage, which is the foundation for any children, but this doesn't mean abandoning your mother; it's about shifting focus and maintaining healthy boundaries while honoring both relationships. 
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How many endings does TBOi have?

The Binding of Isaac features an Epilogue and 11 different endings, and 2 endings were added with the Wrath of the Lamb DLC, totaling over 13 endings. Each one is unlocked after beating the game once.
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Did Isaac and Ishmael ever reconcile?

Yes, while the Bible doesn't detail a specific conversation, Jewish tradition and biblical interpretation strongly suggest Isaac and Ishmael reconciled, symbolized by them burying their father Abraham together in Genesis 25:9, putting aside past conflicts for family duty and shared respect, with later texts showing normalized relations and marriage between their descendants.
 
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How to unlock everything in TBOi?

Unlockables can be gained through doing various tasks, such as destroying enough Poop, beating a chapter for the first time, or defeating a boss in a specific way. Unlockables can be viewed by going to the "Stats" section in the main menu, and then viewing "Secrets" in the left-center of the screen.
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Does hush mean shut up?

In shut the heck up and shut the fudge up, heck and fudge is substituted for more aggressive modifiers. In instant messenger communications, these are in turn often abbreviated to STHU and STFU, respectively. Similar phrases include "hush" and "shush" or "hush up" and "shush up" (which are generally less aggressive).
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How much HP does Toriel have?

Toriel 80 ATK, 80 DEF, 440 HP. Undyne (normal) 50 ATK, 20 DEF, 1500 HP. You're right, Undyne can win.
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Do tears affect mom's knife?

The knife is tied to Isaac's base damage and shot effects (e.g. Spider's Bite). A high tears stat will shorten the charge duration for the knife. The distance the knife is able to travel is fixed at all times and therefore does not depend on the range stat.
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Should a woman carry a knife?

Women are more likely to be attacked if they are alone. Common times include on a run in a secluded area, walking later in the evening, or even in their own homes when they are alone with their intimate and abusive partner. Women should consider carrying a knife for times such as these.
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Can moms knife open the door?

Mom's knife is now able to open the door leading to the Corpse, like it used to in Antibirth. In addition to Mom's Knife, the Forgotten's Bone Scythe and Tainted Eve's Sumptorium are also able to open the door.
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Is Isaac canonically dead?

but personal interpretation does not change the canon. we've had for over a decade. Isaac is dead.
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What does Mom's bra do in Binding of Isaac?

Effects. Upon activation, a picture of Mom wearing this bra will flash over the screen. After this, all the enemies as well as bosses in the room will be frozen for 5 seconds.
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Who is Isaac's dad in Tboi?

In The Binding of Isaac, "Dad" refers to Isaac's absent, struggling father, a key figure in the game's lore reflecting themes of abandonment, addiction (implied by alcoholism/depression in boss stages), and escape, with items like Dad's Key, Dad's Note, and the "Dad" boss fight symbolizing his impact and Isaac's internal struggle, all rooted in the biblical tale of Abraham and Isaac. 
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