Why did Shannen Doherty not take tamoxifen?
Shannen Doherty initially chose not to take tamoxifen after her first breast cancer remission because she believed her cancer was caused by the hormonal stimulation from IVF treatments and didn't want further hormonal exposure from the drug, also wanting to keep the possibility of future conception open. Her oncologist reminded her that tamoxifen could prevent pregnancy, aligning with her desire to have a child, though scientific consensus confirms IVF doesn't cause breast cancer.Can you still get cancer on tamoxifen?
Most studies have found that the increased relative risk of developing endometrial cancer for women taking tamoxifen is two to three times higher than that of an age-matched population 1 2 3. The level of risk of endometrial cancer in women treated with tamoxifen is dose and time dependent.Why did Alyssa Milano and Shannen Doherty not like each other?
Alyssa Milano and Shannen Doherty's feud on Charmed stemmed from on-set personality clashes, creative control disputes, and alleged bullying, with Doherty feeling competitive and blocked from Holly Marie Combs, while Milano sought more power, leading to an ultimatum that resulted in Doherty's departure after Season 3, creating a lingering, well-documented drama that fans still discuss.What happens if I choose not to take tamoxifen?
If you don't take Tamoxifen as prescribed, you significantly increase your risk of breast cancer coming back (recurrence) and dying from the disease, as it blocks estrogen from feeding cancer cells. While stopping may relieve side effects like hot flashes, it also means losing its protection, potentially causing hormonal changes and worsening outcomes, so always talk to your doctor before stopping to discuss managing side effects or alternative strategies.Is it really worth taking tamoxifen?
Often, the benefits of taking tamoxifen outweigh the risks. But it depends on your specific situation. While the drug can successfully prevent breast cancer for many, it can also increase the risk of stroke, uterine cancer or blood clotting issues in others.Shannen Doherty Blames One Person For Delayed Cancer Diagnosis
Why do so many of us quit taking tamoxifen?
Experts say potentially 500,000 women could benefit from taking the drug, but this study indicates that even when women are offered tamoxifen they may not adhere to taking their medication because they think the side effects aren't worth the tradeoff.Why do doctors push tamoxifen?
Tamoxifen works by blocking the oestrogen receptors. It stops oestrogen from telling the cancer cells to grow. As tamoxifen blocks the effects of oestrogen, the aim is to stop breast cancers from developing.What is the most alarming side effect of tamoxifen?
The most serious health risks of tamoxifen, such as endometrial cancer (cancer of the lining of the uterus) and blood clots in the lungs, are rare [115].What is a safer alternative to tamoxifen?
Yes, there are safer alternatives to tamoxifen, with aromatase inhibitors (AIs) like anastrozole, letrozole, and exemestane often preferred for postmenopausal women due to fewer endometrial issues, and raloxifene being a good option for high-risk premenopausal women with lower risks of blood clots and uterine cancers, though each alternative has different side effect profiles, with AIs potentially increasing osteoporosis risk and raloxifene increasing stroke risk in heart disease patients.What happens when you stop taking tamoxifen after 10 years?
Stopping tamoxifen can cause changes in your hormone levels, so you may notice symptoms like hot flashes and mood swings if you are menopausal. However, if tamoxifen was causing these side effects, they may clear up.Why did Jennie Garth and Shannen Doherty not get along?
Jennie Garth and Shannen Doherty's on-set friction on Beverly Hills, 90210 stemmed from personality clashes, intense filming pressures, and a specific prank war involving "Pants Down Day" (Garth) and "Skirt Up Day" (Doherty), which escalated into near-physical altercations, though they later reconciled as adults, acknowledging their youthful immaturity and the industry's tendency to pit women against each other.What did Jason Priestley say about Shannen Doherty?
"Shannen was sick for a very long time, so I think we all knew that eventually something was going to happen. But she seemed so not sick when you would spend time with her," he says. "I'm sure it's because she was just putting on a super brave face and didn't want everyone to know how sick she really was."Who did Shannen Doherty not want at the funeral?
Everyone knows she had disagreements with Jennie Garth from Beverly Hills, 90210 and Alyssa Milano on Charmed and now according to sources close to the funeral planning, those two actresses will not be invited to pay their respects to Shannen. "There's a lot of people that I think would show up that I don't want there.Which breast cancer has the highest recurrence rate?
The breast cancer types with the highest recurrence rates are Triple-Negative Breast Cancer (TNBC) and Inflammatory Breast Cancer (IBC), both known for their aggressive nature, rapid growth, and tendency to return, often within the first few years post-treatment. TNBC lacks estrogen/progesterone receptors and HER2 protein, making it harder to target, while IBC often presents at later stages, increasing recurrence risk.Can you have your ovaries removed instead of taking tamoxifen?
Yes, removing your ovaries (oophorectomy) is an option for premenopausal women with hormone-receptor-positive breast cancer, serving as an alternative to tamoxifen or to enhance its effect by stopping estrogen production, but it leads to immediate menopause and is usually combined with tamoxifen or an aromatase inhibitor (AI) for best results, not a complete replacement for them, especially if fertility is desired.When are you considered cancer-free after breast cancer?
You're often considered "cancer-free" or in complete remission when all detectable signs of breast cancer disappear after treatment, usually after about 5 years in remission, but doctors prefer terms like "no evidence of disease" (NED) because cancer cells can sometimes linger undetected and return later, though the risk drops significantly over time. The timeline and risk vary by breast cancer type, with estrogen-receptor-positive cancers potentially recurring after 5 years, while triple-negative often recurs earlier if at all.What is the new drug replacing tamoxifen?
The third-generation aromatase inhibitors (AIs) anastrozole, exemestane and letrozole have largely replaced tamoxifen as the preferred treatment for hormone receptor – positive breast cancer in postmenopausal women.Where does estrogen come from after menopause?
After menopause, estrogen production shifts from the ovaries to other tissues, primarily fat cells (adipose tissue), which convert adrenal hormones into estrone (E1), the dominant circulating estrogen; the adrenal glands and even some brain tissues also contribute, acting locally rather than systemically.How risky is tamoxifen?
Tamoxifen isn't inherently "bad," but it has significant benefits for estrogen-receptor-positive breast cancer but also serious potential risks, including rare but severe issues like uterine/endometrial cancer, blood clots (deep vein thrombosis, pulmonary embolism), and stroke, alongside common side effects like hot flashes, vaginal discharge, and mood changes, which mimic menopause. Its benefits in preventing recurrence often outweigh risks, but close monitoring for symptoms like unusual bleeding, leg pain, or chest pain is crucial, as is discussing management strategies with your doctor.What vitamins should you avoid while taking tamoxifen?
When taking tamoxifen, you should generally avoid herbal supplements like St. John's Wort, black cohosh, red clover, ginseng, and turmeric/curcumin, as they can decrease its effectiveness by interfering with how the liver processes it (CYP2D6 enzymes). Also be cautious with high-dose antioxidants (Vitamins A, C, E), soy isoflavones, and some citrus, as they may interact, but always discuss any supplement or food with your oncologist before use to ensure safety and efficacy.Is tamoxifen hard on the heart?
Tamoxifen's effect on the heart is complex: it generally shows favorable cardiovascular effects by lowering bad cholesterol (LDL) and reducing heart disease risk, but it's linked to a higher risk of blood clots (like pulmonary embolism), requiring careful consideration of a patient's stroke history. While some suggest it might even protect against heart muscle damage in certain conditions, it's crucial to monitor cardiovascular health due to potential risks and interactions, especially with other medications, notes the American Heart Association and the National Institutes of Health.Why am I so tired on tamoxifen?
You're tired on Tamoxifen because fatigue is a very common side effect, often described as extreme exhaustion not relieved by rest, stemming from how the drug affects your body (mimicking menopause, disrupting sleep) and potentially other factors like anemia or poor nutrition; pacing yourself, gentle exercise, and talking to your doctor are key management strategies.What are the side effects of tamoxifen for eyes?
Tamoxifen can cause eye side effects, primarily affecting the retina and lens, including dry eyes, blurred vision, color vision changes (especially blues/greens), light sensitivity, and potentially serious issues like cataracts, macular edema, and crystalline deposits (retinopathy), often linked to dose and duration; regular eye exams are crucial for early detection, notes the American Academy of Ophthalmology and Mayo Clinic.Do most people do well on tamoxifen?
Although the side effects of tamoxifen cause some women to interrupt or discontinue taking it, study coauthor Ann H. Partridge, MD, MPH, FASCO, stressed in an interview with The ASCO Post that tamoxifen is “effective therapy, not 100% effective, but it does cut the risk on average in half. It improves mortality by 30%.What happens when you stop taking tamoxifen after 5 years?
When you stop tamoxifen after 5 years, your body experiences hormonal shifts that can alleviate side effects like hot flashes, but also increases breast cancer recurrence risk, requiring close monitoring, potential lifestyle changes for bone/heart health, and a discussion with your doctor about transitioning or continuing treatment based on your individual cancer risk profile and genomic testing.
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