Can I unlock the lost with Azazel?

Yes, you can use Azazel as the final character in a specific sequence of deaths to unlock The Lost in older versions (Rebirth), but in newer versions (Afterbirth+ and Repentance), the method changed to dying with the Missing Poster trinket in a sacrifice room after specific deaths with Isaac, Maggie, and Judas, making Azazel less central to the unlock itself, but still a strong character to get to Satan for that step in the old method.
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How do you unlock the lost?

To unlock The Lost in The Binding of Isaac, you must perform a specific sequence of deaths in Rebirth, or, in Afterbirth and later versions, find the Missing Poster trinket and die in a Sacrifice Room while holding it, after first unlocking the Missing Poster by beating The Lamb as Isaac. The original, complex four-death sequence (Isaac -> Maggie -> Judas -> Azazel) is for the base Rebirth game, while the Missing Poster method is used in expansions like Afterbirth and Repentance.
 
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Which characters unlock The Lost?

Unlocking The Lost in Rebirth
  • Isaac must die to a. Mulliboom in Chapter 1.
  • Magdalene must die to her own. Bomb in Chapter 2.
  • Judas must die to. Mom. Being killed by any monster spawned by Mom will spoil the entire attempt at unlocking The Lost.
  • Finally, Azazel must die to Satan. You must die in his second phase.
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Can you only unlock the lost as Isaac?

To unlock the Lost, all you need is beat the Lamb with Isaac once and then find the Missing Poster and a Sacrifice Room. One could argue that a player needs to know about the specific ritual needed for the unlock, but the same goes for unlocking tainted characters anyway.
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What is the hardest boss in The Binding of Isaac?

The hardest boss in The Binding of Isaac is widely considered to be Delirium, due to its chaotic, unpredictable teleporting, rapid transformations, and intense bullet-hell attacks, making it nearly impossible to no-hit; however, Mother and The Beast/Dogma (from Repentance) are also extremely challenging final encounters with unique, difficult mechanics, while The Scourge and early-game bosses like Headless Horseman are noted for their difficulty in specific contexts. 
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How To Unlock The Lost

Is the lost worth unlocking in Isaac?

The Lost is the ultimate challenge in The Binding of Isaac: Rebirth. He has bad stats and can never have health, which means he will always die in one hit. But The Lost also unlocks some of the best and most fun items in the game and is needed to get the final achievement, True Platinum God.
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Can the lost take devil deals?

Yes, The Lost in The Binding of Isaac can take Devil Deals for free, which is a huge advantage, but they can only select one item per room; taking one item causes all other deals in that room to disappear, making them powerful for getting strong items early without health cost. This is a core strategy, often preferred over Angel Deals because The Lost's free health (via Holy Mantle) makes the risk/reward of Devil Deals very favorable.
 
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How to get Holy Mantle for the lost?

To unlock the Holy Mantle for The Lost, you must donate 879 cents to the Greed Donation Machine after beating Greed Mode in The Binding of Isaac: Rebirth and its expansions, making The Lost significantly easier by giving them a free hit shield in every room. This is a crucial unlock, best achieved by playing Greed Mode, saving money, and using characters like Isaac or Magdalene to reach the target amount.
 
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How many endings are in The Binding of Isaac?

The Binding of Isaac features an Epilogue and 11 different endings, and 2 endings were added with the Wrath of the Lamb DLC, totaling over 13 endings. Each one is unlocked after beating the game once.
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What DLCs are available for The Binding of Isaac?

Since release, Rebirth has had four expansions: Afterbirth (2015), Afterbirth+ (2017), Repentance (2021) and Repentance+ (2024) with more game content and gameplay modes.
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Is the lost in binding of Isaac Rebirth?

Yes, "The Lost" is a secret, very difficult character in The Binding of Isaac: Rebirth, unlocked by performing a specific sequence of four deaths with different characters (Isaac, Maggie, Judas, Azazel) in a particular order, with each death requiring a specific cause (Mulliboom, own bomb, Mom's foot, Satan) in the original version. This process was later simplified in the Afterbirth DLC and subsequent versions to dying in a Sacrifice Room while holding the Missing Poster trinket.
 
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How many characters are in Repentance?

There are 34 playable characters in The Binding of Isaac: Repentance, consisting of the original 17 characters and their unique "Tainted" counterparts, with each Tainted version offering a completely different gameplay experience. This total includes new additions like Bethany and Jacob & Esau from Repentance, plus all characters from the base game and previous DLCs (Rebirth, Afterbirth, Afterbirth+).
 
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How to unlock a secret door in Isaac?

To unlock the Strange Door in The Binding of Isaac: Repentance, you first need to beat Mother on the alternate path to unlock it, then find it in the starting room of Depths/Necropolis II and give it The Polaroid or The Negative to enter the path to Home, requiring a teleport out of Mom's room after beating Mom. 
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How do you unlock the lost TBOi?

To unlock The Lost in The Binding of Isaac (with Afterbirth DLC or later), you must first unlock the Missing Poster trinket by defeating The Lamb as Isaac, then find the Missing Poster in a run and die on the spikes in a Sacrifice Room while holding it, ensuring you're not teleported away. The original Rebirth method involved a specific sequence of four character deaths, but the Missing Poster method works for all DLCs. 
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What are some famous "forgotten" figures?

10 People Forgotten By History
  • 10 Matthias Sindelar.
  • 9 Alexander Hamilton.
  • 8 Henrietta Lacks.
  • 7 Jack Phillips.
  • 6 Edith Wilson.
  • 5 Hedy Lamarr.
  • 4 Helen Sharman.
  • 3 Percy Julian.
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Can you use mysterious paper to unlock the lost?

Yes, you can unlock The Lost in The Binding of Isaac: Rebirth (and later) using Mysterious Paper, but it's a low-chance, RNG-heavy method where the Paper must mimic the Missing Poster trinket and you die in a Sacrifice Room. It works because Mysterious Paper cycles through effects like Polaroid, Negative, Missing Poster, and A Missing Page, so dying while it mimics Missing Poster gives you the needed revival to unlock The Lost. 
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Can you enter Curse Rooms as the lost?

Care must still be taken when making use of curse rooms, as any damage taken inside of it will nullify the Holy Mantle charge, trapping the Lost inside unless he has some way to generate a shield, teleport out, or extra lives.
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How to unlock everything in TBOi?

Unlockables can be gained through doing various tasks, such as destroying enough Poop, beating a chapter for the first time, or defeating a boss in a specific way. Unlockables can be viewed by going to the "Stats" section in the main menu, and then viewing "Secrets" in the left-center of the screen.
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Does a metal plate work on The Lost?

Metal Plate: Have a chance of blocking or deflecting projectiles that come into contact with the Lost.
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How to unlock tainted lost?

To unlock Tainted Lost in The Binding of Isaac: Repentance, play as the regular Lost, reach the Home floor, and use a Red Key, Cracked Key, or Soul of Cain to open a secret closet in the wall before Mom's bedroom. This process involves using a key item on the Home floor to reveal the Tainted character's closet, similar to unlocking other Tainted characters, with the first visit to Home dropping the Red Key in Mom's Chest.
 
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