Should I tell Dr. Li that Virgil is alive?

Whether you tell Dr. Li about Virgil (Brian Virgil) being alive in Fallout 4 depends on your goal, but generally, you should give her Virgil's log holotape during the Brotherhood of Steel quest "From Within" to progress the quest and persuade her to leave the Institute, as she won't believe you without proof anyway, and showing her his transformation evidence is key to convincing her he's alive and worthy of saving. If you tell her he's alive without the log, she'll call you a liar, but presenting the log makes her realize the Institute's cruelty, leading her to join you.
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Should you let Virgil live?

Whether you should let Virgil live in Fallout 4 depends on your roleplaying goals: saving him offers a chance at a "good" ending, letting him die fulfills Brotherhood orders for rewards (like the T-60 Helm), but you can also cure him and then lie to the Brotherhood to avoid killing him, achieving a more moral outcome with similar rewards. Curing him lets him become human and provides ongoing help, while killing him ends his storyline but fulfills BoS demands.
 
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What happens if you tell Virgil you can't find the serum?

One can also lie to Virgil through a sequence of three speech checks (the difficulty of each one increases each time), claiming that the serum wasn't there. After the first two checks, the player character still has the option to give the serum to Virgil through breaking and re-initiating dialogue with him.
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What evidence does Doctor Li need?

In order to ensure Doctor Li's trust, one must agree to recover evidence regarding an accident that supposedly killed her colleague, Doctor Virgil. His former lab is in a sealed section of the Bioscience Division.
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Can you convince Virgil to come back to the Institute?

The third entry on Virgil's terminal suggests that he is losing his memory, and as a result, his sanity, due to being a mutant. Even if the player character becomes director of the Institute and subsequently gives Virgil the serum, there is no option via dialogue to have the now-human Virgil return to the Institute.
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Fallout 4's SECRET Choices Explained in 17 Minutes

Does Piper get mad if you join the Brotherhood of Steel?

She also has an open dislike for the Brotherhood of Steel due to their self-serving nature, technology hoarding, anti-synth policies, and in her eyes, lousy fashion sense. Thus she will react negatively to any pro-Brotherhood choices.
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Which faction is the best to side with in Fallout 4?

There's no single "best" faction in Fallout 4; it depends on your playstyle and morals, but generally, the Railroad (for stealth/espionage rewards like Ballistic Weave) and Brotherhood of Steel (BoS) (for Power Armor/heavy weapons) offer great perks, while the Minutemen (for a true "good guy" feel and settlement focus) are morally sound but less rewarding, and the Institute is often seen as the villainous, technologically advanced, but morally corrupt choice.
 
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Who should I blame for killing Nelson in Fallout 4?

Shifting the blame requires a Charisma check to succeed. If it fails, a Charisma check to apologize can be used to avoid Malcolm's hitsquad. If it succeeds, the player character can optionally implicate Marowski or Paul Pembroke as Nelson's killer.
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What are the chances of getting the perfectly preserved pie in Fallout 4?

In Fallout 4, the chance for a Port-A-Diner to dispense a Perfectly Preserved Pie increases with your base Luck stat and the number of failed attempts, using the formula: Chance (%) = ((Luck x 4) + Attempts) / 20, with max Luck (10) giving a 2% chance on the first try, but with stacking boosts and enough attempts, you can significantly improve odds or even guarantee it, especially via the Nuka-World DLC's guaranteed machine.
 
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Is it better to return or deliver the Deathclaw egg in Fallout 4?

Putting the helmet on after completing the quest by returning the egg will immediately turn the deathclaw hostile. Berry Mentats will also trigger a hostile status. If one delivers the egg for the reduced reward having stolen it back from the nest a pristine deathclaw egg may remain in the player's inventory.
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How to get Virgil's cure?

To get Virgil's Cure in Fallout 4, you must enter the Institute's FEV Lab, fight through security (turrets, Assaultrons), find the "Experimental Serum" in the final Super Mutant testing room, and return it to Virgil in the Glowing Sea for him to test, eventually turning him back human after a few days. You can access the FEV Lab by joining the Institute or during the main questline's invasion, using hacking or an alternative path through storage rooms if needed.
 
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Can you get Lorenzo's helmet?

You can't normally get Lorenzo's helmet (Crown) in Fallout 4 as it's unobtainable vanilla, but you can use PC console commands to spawn it (player.placeatme 001467F5) or force it onto an NPC/armor rack, though it won't show in your inventory and offers little stats, but mods might make it wearable for console players, says the Fallout Wiki and Fandom.
 
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Is Lorenzo a bad guy in Fallout 4?

Lorenzo Cabot from Fallout 4 isn't definitively evil; he's a morally complex character, driven insane and granted immense psychic power by an ancient artifact, the Eye of Ra, making him dangerously unstable and homicidal, though some players see him as a victim of his selfish family who used him as an immortal source for their serum. The choice to free or kill him is a major moral dilemma in the game, with valid arguments for both sides, as he commits atrocities but also endures centuries of imprisonment. 
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Who killed the Supreme Arbiter?

In The Outer Worlds 2, the character Virgil confesses to killing the Supreme Arbiter during the quest "Casting Off the Veil," admitting he murdered their mentor, who was revealed to be a traitor, to prevent further harm, though players have choices in how to handle the situation with Tristan. 
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Who is the real villain in Fallout 4?

The main villain in Fallout 4 is Shaun, also known as Father, the leader of the high-tech Institute and the adult son of the player character, the Sole Survivor, who seeks to replace humanity with synths and uses his parent as a pawn in his plan to take over the Commonwealth. Other antagonists include Conrad Kellogg, the mercenary who kidnaps Shaun, and the entire Institute, as well as other factions like the Minutemen, Brotherhood of Steel, and Railroad having morally grey or villainous elements depending on player choice. 
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Do I actually have to pay Hancock 1000 caps?

Hancock is unhappy with the Survivor killing his friend and bodyguard Fahrenheit, and demands 1,000 caps compensation, which can be reduced to 750, 500 and 200 caps successively with increasingly harder Speech checks, and tasks the Sole Survivor with confronting and killing Bobbi to retrieve those caps.
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Who is the best ally in Fallout 4?

Once you maximize your bond, unique affinity perks unlock, and you may find them incredibly useful during your upcoming adventures.
  • Fallout 4: All Companions Ranked – Best Allies for the Wasteland.
  • Dogmeat.
  • Curie.
  • Paladin Danse.
  • Porter Gage (Nuka-World DLC)
  • Strong.
  • Preston Garvey.
  • Nick Valentine.
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Can I join all factions in Fallout 4?

Yes, you can join all four major factions in Fallout 4 (Minutemen, Brotherhood of Steel, Railroad, Institute) early on and do quests for them, but the main story forces you to choose one for the endgame, leading to the destruction of others, though the Minutemen can survive alongside the BoS and Railroad if you use them for the final push against the Institute. You'll hit "points of no return" where your choices make factions hostile, so saving before major quests like {!nav}Mass Fusion{/nav} allows you to explore all endings in one playthrough. 
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What faction has the best ending in Fallout 4?

The Minutemen ending is the best ending. The BoS ending is the natural ending. If the Sole Survivor didn't exist, I feel the Brotherhood would take over the wasteland.
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Is Piper a synth?

No, Piper Wright from Fallout 4 is not confirmed to be a synth; while some in-game speculation and theories exist (like a quest involving a fake Piper) and some players enjoy the mystery, lore generally indicates she's a human journalist, and there's no solid evidence she carries a synth component or has synth traits.
 
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Can you be a Minuteman and Brotherhood of Steel?

Yes, in Fallout 4, you can join and work with both the Minutemen and the Brotherhood of Steel (BoS) simultaneously for most of the game, as they don't inherently conflict, but you'll eventually reach a point where you must choose one faction's path to complete the main quest, though you can keep both alive by siding with the Minutemen for the ending and potentially even get unique dialogue for being affiliated with both. The Minutemen are your personal militia, while the BoS focuses on tech and synths, allowing for dual membership until key decisions force a final allegiance. 
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Will Danse become hostile if I destroy the Brotherhood?

Yes, destroying the Brotherhood of Steel will make Paladin Danse hostile or cause him to stop interacting with you, even if you've completed his personal quest ("Blind Betrayal") and he's been reinstated; he still deeply believes in the BoS's mission, so siding against them effectively makes you his enemy, preventing him from being a companion, though some players report a temporary bug where he remains friendly before eventually turning. To keep him long-term, you must either remain loyal to the BoS or side with the Minutemen and avoid conflict with the Brotherhood. 
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